An association between mineral metabolism and the renin-aldosterone system in human hypertension

J Hum Hypertens. 1989 Apr;3(2):137-40.

Abstract

In recent years abnormalities of calcium metabolism have been described in human hypertension. In this study, the relationships between indices of calcium metabolism and the renin-aldosterone system were studied in 39 subjects with untreated essential hypertension. No significant associations were found between the major determinants of calcium metabolism (plasma ionised calcium, parathyroid hormone and 1,25(OH)2-vitamin D) and the renin-aldosterone system. Serum magnesium was, however, positively correlated to plasma renin activity (PRA) (r = 0.38, P less than 0.05) while both 24 h urinary excretion of calcium and cAMP were found to be correlated to both PRA and urinary aldosterone in a positive way (r = 0.39-0.42, P less than 0.01 and r = 0.33-0.57, P less than 0.01, respectively). In this study there was no other evidence of any major influence of the renin-aldosterone status on the calcium balance in human hypertension. The urinary leak of calcium might be determined by the action of the renin-aldosterone system.

MeSH terms

  • Adult
  • Aldosterone / metabolism*
  • Calcium / urine
  • Cyclic AMP / urine
  • Female
  • Humans
  • Hypertension / blood
  • Hypertension / metabolism*
  • Hypertension / urine
  • Magnesium / blood
  • Male
  • Middle Aged
  • Minerals / metabolism*
  • Renin / blood
  • Renin / metabolism*
  • Sodium / urine

Substances

  • Minerals
  • Aldosterone
  • Sodium
  • Cyclic AMP
  • Renin
  • Magnesium
  • Calcium