Abstract
In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C(+) patients survived; in contrast, only 22% of GBV-C(-) patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Coinfection / epidemiology*
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Coinfection / virology
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Female
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Flaviviridae Infections / epidemiology*
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Flaviviridae Infections / virology
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GB virus C / genetics
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GB virus C / isolation & purification*
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Hemorrhagic Fever, Ebola / complications*
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Hemorrhagic Fever, Ebola / mortality
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Hepatitis, Viral, Human / epidemiology*
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Hepatitis, Viral, Human / virology
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Humans
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Infant
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Infant, Newborn
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Male
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Middle Aged
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Molecular Sequence Data
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RNA, Viral / genetics
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Sequence Analysis, DNA
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Sierra Leone / epidemiology
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Survival Analysis
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Young Adult
Associated data
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GENBANK/KM670096
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GENBANK/KM670097
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GENBANK/KM670098
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GENBANK/KM670099
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GENBANK/KM670100
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GENBANK/KM670101
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GENBANK/KM670102
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GENBANK/KM670103
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GENBANK/KM670104
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GENBANK/KM670105
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GENBANK/KM670106
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GENBANK/KM670107
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GENBANK/KM670108
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GENBANK/KM670109
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GENBANK/KM670110