Bifidobacterium longum bacteremia in preterm infants receiving probiotics

Clin Infect Dis. 2015 Mar 15;60(6):924-7. doi: 10.1093/cid/ciu946. Epub 2014 Dec 3.

Abstract

Administration of probiotics to premature newborns has been shown to prevent necrotizing enterocolitis and reduce all-cause mortality. In our hospital, we documented 2 cases of Bifidobacterium longum subspecies infantis bacteremia in newborns receiving probiotics. By comparative genomics, we confirmed that the strains isolated from each patient originated from the probiotics.

Keywords: Bifidobacterium; genome sequence; newborn; probiotics; sepsis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Bacteremia / drug therapy*
  • Bifidobacteriales Infections / microbiology*
  • Bifidobacterium / isolation & purification*
  • Bifidobacterium / pathogenicity
  • Enterocolitis, Necrotizing / microbiology
  • Enterocolitis, Necrotizing / prevention & control*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature / blood
  • Infant, Premature, Diseases / microbiology*
  • Infant, Very Low Birth Weight
  • Phylogeny
  • Probiotics / adverse effects*
  • Probiotics / therapeutic use
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents