Purloined mechanisms of bacterial immunity can cure muscular dystrophy

James G Tidball; Carmen Bertoni

doi:10.1016/j.cmet.2014.11.011

Purloined mechanisms of bacterial immunity can cure muscular dystrophy

Cell Metab. 2014 Dec 2;20(6):927-9. doi: 10.1016/j.cmet.2014.11.011.

Authors

James G Tidball¹, Carmen Bertoni²

Affiliations

¹ Molecular, Cellular and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, CA 90095-7239, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1732, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095-7239, USA. Electronic address: jtidball@lifesci.ucla.edu.
² Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA.

Abstract

Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes muscular dystrophy (Long et al., 2014).

MeSH terms

Animals
Bacteria / genetics*
Disease Models, Animal
Dystrophin / genetics*
Mice
Muscular Dystrophy, Duchenne / genetics*
Muscular Dystrophy, Duchenne / therapy
Mutation

Substances

Dystrophin

Abstract

MeSH terms

Substances

Grants and funding