: We reported a case of a young athlete with an underlying myocardial bridging in the left anterior descending coronary artery (LAD) causing myocardial ischemia suspected by contrast exercise stress echocardiography and confirmed by computed tomography coronary angiography. Our report demonstrated that a specific stress echocardiography pattern consisting of reversible focal buckling in the end-systolic to early-diastolic motion of the septum may suggest the presence of an underlying myocardial bridging in the LAD.