Flexible organic electrochemical transistors for highly selective enzyme biosensors and used for saliva testing

Adv Mater. 2015 Jan 27;27(4):676-81. doi: 10.1002/adma.201404378. Epub 2014 Dec 2.

Abstract

Flexible organic electrochemical transistors (OECTs) are successfully used as high-performance enzyme biosensors, such as uric acid (UA) and cholesterol sensors. The sensitivity and selectivity of the sensors can be simultaneously enhanced by co-modifying the gate electrodes with positively/negatively charged bilayer polymer films and enzymes. These OECT-based UA sensors are successfully utilized for non-invasive UA detection in human saliva.

Keywords: biosensors; enzymes; organic electrochemical transistors; selectivity; uric acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Electrochemistry
  • Electrodes
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism*
  • Humans
  • Hydrogen Peroxide / chemistry
  • Organic Chemicals / chemistry*
  • Platinum / chemistry
  • Polyethylene Terephthalates / chemistry
  • Polystyrenes / chemistry
  • Saliva / chemistry*
  • Thiophenes / chemistry
  • Transistors, Electronic*
  • Urate Oxidase / chemistry
  • Urate Oxidase / metabolism
  • Uric Acid / analysis*
  • Uric Acid / chemistry

Substances

  • Enzymes, Immobilized
  • Organic Chemicals
  • Polyethylene Terephthalates
  • Polystyrenes
  • Thiophenes
  • poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)
  • Uric Acid
  • Platinum
  • Hydrogen Peroxide
  • Urate Oxidase