MSP: an emerging player in metabolic syndrome

Cytokine Growth Factor Rev. 2015 Feb;26(1):75-82. doi: 10.1016/j.cytogfr.2014.10.007. Epub 2014 Oct 31.

Abstract

MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R). Since its discovery, MSP has been demonstrated to play a key role in regulating inflammation in the peripheral tissues of multiple disease models. Recent evidences also point toward a beneficial role of MSP in the regulation of hepatic lipid and glucose metabolism, thereby implicating MSP as a crucial regulator in maintaining metabolic homeostasis while simultaneously suppressing inflammatory processes. In this review, we discuss the recent advances that demonstrate the significance of MSP in metabolic syndrome and build a strong case supporting its therapeutic potential.

Keywords: Inflammation; MSP; Metabolic syndrome; RON.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Hepatocyte Growth Factor / physiology*
  • Hepatocyte Growth Factor / therapeutic use*
  • Homeostasis
  • Humans
  • Inflammation
  • Lipid Metabolism
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / physiopathology*
  • Mice
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins / therapeutic use*
  • Rats
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins
  • macrophage stimulating protein
  • Hepatocyte Growth Factor
  • Receptor Protein-Tyrosine Kinases