Abstract
We have studied the effect of hyperthyroidism and hypothyroidism on the lactating rat mammary gland number of beta-adrenergic receptors and basal intracellular cyclic AMP levels. We also describe the effects of isoproterenol, cholera toxin and forskolin challenge on these parameters. Using cyclic AMP levels as an indication of receptor functionality our results indicate that both thyroid states are accompanied by a decrease in the response to beta-adrenergic receptor stimulation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Membrane / drug effects
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Cell Membrane / metabolism
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Cyclic AMP / metabolism
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Dihydroalprenolol / metabolism
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Female
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Heart Transplantation
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Mammary Glands, Animal / drug effects
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Mammary Glands, Animal / metabolism*
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Mammary Glands, Animal / transplantation
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, beta / metabolism*
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Thyroid Hormones / pharmacology*
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Transplantation, Homologous
Substances
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Receptors, Adrenergic, beta
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Thyroid Hormones
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Dihydroalprenolol
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Cyclic AMP