Significance of association of HLA-C and HLA-E with psoriatic arthritis

Hum Immunol. 2014 Dec;75(12):1188-91. doi: 10.1016/j.humimm.2014.10.005. Epub 2014 Oct 16.

Abstract

Psoriatic arthritis (PsA) is a complex genetic disorder that results from an interplay between multiple genetic and environmental factors. The aim of the study was to assess the significance of the association between the HLA-C and HLA-E allelic groups and PsA. Our results confirm the association between HLA-C(∗)06 and PsA (OR=5.16, p<0.0001). Furthermore, HLA-C(∗)06-positive patients develop more severe disease (p<0.01) and more frequently present with polyarticular pattern of PsA (p=0.08). Additionally our study revealed that the HLA-C(∗)02 allele was more frequently observed in PsA patients (OR=5.40, p<0.0005) and also that the HLA-E(∗)01:01 allele was significantly over-represented among HLA-C(∗)02-negative patients in comparison to healthy individuals (OR=6.44, p=0.045). Therefore these results suggest that the HLA-E and HLA-C(∗)02 molecules may also play an important role in determination immune response contributing to the PsA development.

Keywords: Disease phenotype; HLA-C; HLA-E; Polish population (Poles); Psoriatic arthritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Psoriatic / genetics*
  • Arthritis, Psoriatic / immunology
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • HLA-C Antigens / genetics*
  • HLA-C Antigens / immunology
  • HLA-E Antigens
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class I / immunology
  • Humans
  • Male
  • Middle Aged
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / immunology

Substances

  • HLA-C Antigens
  • HLA-C*02 antigen
  • HLA-C*06 antigen
  • Histocompatibility Antigens Class I