Stimuli-responsive bile acid-based metallogels forming in aqueous media

Virpi Noponen; Katri Toikkanen; Elina Kalenius; Riikka Kuosmanen; Hannu Salo; Elina Sievänen

doi:10.1016/j.steroids.2014.10.001

Stimuli-responsive bile acid-based metallogels forming in aqueous media

Steroids. 2015 May:97:54-61. doi: 10.1016/j.steroids.2014.10.001. Epub 2014 Nov 3.

Authors

Virpi Noponen¹, Katri Toikkanen², Elina Kalenius², Riikka Kuosmanen², Hannu Salo², Elina Sievänen³

Affiliations

¹ University of Jyväskylä, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland. Electronic address: virpi.noponen@gmail.com.
² University of Jyväskylä, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland.
³ University of Jyväskylä, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland. Electronic address: elina.i.sievanen@jyu.fi.

PMID: 25448361
DOI: 10.1016/j.steroids.2014.10.001

Abstract

The synthesis and gelation properties of a picolinic acid conjugated bile acid derivative in the presence of metal salts along with the stimuli-responsiveness of the systems are reported. The gels are formed in the presence of Cu(2+) ions in the solvent systems composed of 30-50% of organic solvent (MeOH, acetonitrile, or acetone) in water. The gels respond to various stimuli: they can be formed upon sonication or shaking, and their gel-sol transformation can be triggered by a variety of chemical species. NMR, MS, and SEM techniques are exploited in order to gain a deeper insight on the self-assembled systems.

Keywords: Bile acid; Metallogel; Picolinic acid; Self-assembly; Stimuli-responsive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Amides / chemistry
Bile Acids and Salts / chemistry*
Copper / chemistry*
Gels / chemical synthesis*
Gels / chemistry
Molecular Structure
Picolinic Acids / chemistry

Substances

Amides
Bile Acids and Salts
Gels
Picolinic Acids
Copper
picolinic acid