Evaluation of survival and neurological deficit in rats in the new model of global transient cerebral ischemia

G A Chernysheva; V I Smol'yakova; A N Osipenko; M B Plotnikov

doi:10.1007/s10517-014-2721-8

Evaluation of survival and neurological deficit in rats in the new model of global transient cerebral ischemia

Bull Exp Biol Med. 2014 Dec;158(2):197-9. doi: 10.1007/s10517-014-2721-8. Epub 2014 Nov 29.

Authors

G A Chernysheva¹, V I Smol'yakova, A N Osipenko, M B Plotnikov

Affiliation

¹ Laboratory of Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.

PMID: 25430646
DOI: 10.1007/s10517-014-2721-8

Abstract

We propose a modification to rat model of transient global cerebral ischemia with four-vessel occlusion avoiding pneumothorax and minimizing the consequences of surgery. Survival and neurological deficit in rats in this model was studied over 5 days.

MeSH terms

Animals
Disease Models, Animal*
Ischemic Attack, Transient / etiology
Ischemic Attack, Transient / physiopathology*
Ischemic Attack, Transient / surgery
Male
Nervous System Diseases / diagnosis
Nervous System Diseases / pathology*
Rats
Rats, Wistar
Survival Analysis