A new bibenzyl derivative with nuclear factor-kappaB inhibitory activity from Schefflera arboricola (Araliaceae)

Nat Prod Res. 2015;29(12):1139-44. doi: 10.1080/14786419.2014.983506. Epub 2014 Nov 26.

Abstract

A new bibenzyl derivative (1), 4-acetoxy-3,5,3',4'-tetramethoxybibenzyl, along with eight known compounds (2-9), was isolated from the twigs and leaves of Schefflera arboricola (Araliaceae). The isolated compounds were elucidated mainly by means of one-dimensional, two-dimensional NMR and MS, and by comparison with the literature data. Compounds 2-5 and 7-9 are first reported from this plant. In the in vitro assays, compound 1 displayed moderate nuclear factor-kappaB inhibitory activity.

Keywords: Schefflera arboricola; bibenzyl derivative; nuclear factor-kappaB inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Araliaceae / chemistry*
  • Bibenzyls / chemistry*
  • Cell Line
  • Mice
  • Molecular Structure
  • NF-kappa B / antagonists & inhibitors*
  • Plant Leaves / chemistry
  • Plant Stems / chemistry

Substances

  • 4-acetoxy-3,5,3',4'-tetramethoxybibenzyl
  • Bibenzyls
  • NF-kappa B