Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery

Adv Mater. 2015 Jan 14;27(2):215-22. doi: 10.1002/adma.201404256. Epub 2014 Nov 25.

Abstract

A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).

Keywords: gene delivery; large mesopores; mesoporous organosilicas; nuclear-targeted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Cell Survival
  • Gene Products, tat / genetics
  • Gene Transfer Techniques*
  • Genetic Therapy / methods
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Magnetic Resonance Spectroscopy
  • Micelles*
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Particle Size
  • Plasmids / genetics
  • Porosity
  • Silicon Dioxide / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Spectrum Analysis, Raman

Substances

  • Biocompatible Materials
  • Gene Products, tat
  • Micelles
  • Silicon Dioxide