Stealing VEGF from thy neighbor

Courtney K Domigan; M Luisa Iruela-Arispe

doi:10.1016/j.cell.2014.10.008

Stealing VEGF from thy neighbor

Cell. 2014 Oct 23;159(3):473-4. doi: 10.1016/j.cell.2014.10.008.

Authors

Courtney K Domigan¹, M Luisa Iruela-Arispe²

Affiliations

¹ Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
² Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA. Electronic address: arispe@mcdb.ucla.edu.

PMID: 25417099
DOI: 10.1016/j.cell.2014.10.008

Abstract

The distribution and patterning of blood vessels is controlled by vascular endothelial growth factor (VEGF), which is precisely regulated throughout its life cycle. Okabe et al. show that VEGF is titrated away from the endothelium by adjacent neurons via endocytosis, regulating density and trajectory of blood vessels.

Publication types

Comment

MeSH terms

Animals
Neovascularization, Physiologic*
Neurons / metabolism*
Retina / growth & development*
Vascular Endothelial Growth Factor A / metabolism*

Substances

Vascular Endothelial Growth Factor A

Grants and funding

T32 HL069766/HL/NHLBI NIH HHS/United States