Role of innate immunity in pregnant patients with vulvovaginal infections in the development of intrauterine infection in the newborn

Bull Exp Biol Med. 2014 Nov;158(1):74-6. doi: 10.1007/s10517-014-2695-6. Epub 2014 Nov 19.

Abstract

A total of 115 pregnant women were examined: 59 patients with opportunistic vulvovaginal infections and 56 without infection. Congenital immunity parameters (TLR-2, NF-κB, and IL-2 receptors in placental tissue) were studied by immunohistochemical methods. Realization of congenital infection was associated with activation of IL-6 receptors and TLR-2 in the placenta and an increase of NF-κB level. These changes seemed to reflect the strained status of congenital immunity and were responsible for the intensity of local inflammatory response.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Chorionic Villi / metabolism
  • Chorionic Villi / microbiology
  • Female
  • Humans
  • Immunity, Innate*
  • Infant, Newborn
  • NF-kappa B / metabolism
  • Placenta / immunology
  • Placenta / metabolism
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology*
  • Pregnancy Outcome
  • Receptors, Interleukin-6 / metabolism
  • Toll-Like Receptor 2 / metabolism
  • Uterine Diseases / immunology*
  • Uterine Diseases / microbiology
  • Vaginosis, Bacterial / immunology*
  • Young Adult

Substances

  • NF-kappa B
  • Receptors, Interleukin-6
  • TLR2 protein, human
  • Toll-Like Receptor 2