Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

Chembiochem. 2015 Jan 2;16(1):59-63. doi: 10.1002/cbic.201402512. Epub 2014 Nov 7.
No abstract available

Keywords: drug discovery; enzymes; inhibitors; phosphorylation; protein structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Benzamides / chemistry*
  • Catalytic Domain
  • Crystallography, X-Ray
  • Death-Associated Protein Kinases / antagonists & inhibitors*
  • Death-Associated Protein Kinases / chemistry*
  • Death-Associated Protein Kinases / genetics
  • Enzyme Assays
  • Gene Expression Regulation
  • High-Throughput Screening Assays
  • Humans
  • Kinetics
  • Ligands
  • Microfluidic Analytical Techniques
  • Models, Molecular
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Binding
  • Protein Kinase Inhibitors / chemistry*
  • Pyridazines / chemistry*
  • Receptors, N-Methyl-D-Aspartate / chemistry*
  • Receptors, N-Methyl-D-Aspartate / genetics

Substances

  • Benzamides
  • Ligands
  • NR2B NMDA receptor
  • Protein Kinase Inhibitors
  • Pyridazines
  • Receptors, N-Methyl-D-Aspartate
  • DAPK1 protein, human
  • Death-Associated Protein Kinases