Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment

Blood. 2014 Nov 6;124(19):3031-3. doi: 10.1182/blood-2014-09-600254.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blood Coagulation / drug effects
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism
  • Endothelial Protein C Receptor
  • Factor VIIa / metabolism
  • Factor VIIa / pharmacology*
  • Hemophilia A / drug therapy*
  • Hemophilia A / metabolism
  • Mice, Mutant Strains
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Receptors, Cell Surface / metabolism

Substances

  • Endothelial Protein C Receptor
  • Procr protein, mouse
  • Receptors, Cell Surface
  • Factor VIIa