CD4 helpers put tissue-resident memory cells in their place

Laura K Mackay; Francis R Carbone

doi:10.1016/j.immuni.2014.09.018

CD4 helpers put tissue-resident memory cells in their place

Immunity. 2014 Oct 16;41(4):514-5. doi: 10.1016/j.immuni.2014.09.018.

Authors

Laura K Mackay¹, Francis R Carbone²

Affiliations

¹ The Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia.
² The Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia. Electronic address: fcarbone@unimelb.edu.au.

PMID: 25367567
DOI: 10.1016/j.immuni.2014.09.018

Abstract

The regulation of tissue-resident memory cell development is poorly understood. In this issue of Immunity, Laidlaw et al. (2014) demonstrate that CD4(+) T cells promote development of lung-resident memory cells by limiting T-bet expression and directing CD8(+) T cells to the airway epithelium.

Publication types

Comment

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / immunology*
Immunologic Memory*
Influenza A Virus, H3N2 Subtype / immunology*
Lung / immunology*
Orthomyxoviridae Infections / immunology*
T-Box Domain Proteins / biosynthesis*

Substances

T-Box Domain Proteins
T-box transcription factor TBX21