Abstract
The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / immunology
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Autoimmune Diseases / genetics*
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Autoimmune Diseases / immunology
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Autoimmune Diseases / pathology
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Gene Expression Regulation
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Humans
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NF-kappa B / genetics*
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NF-kappa B / immunology
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Neoplasms / genetics*
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Neoplasms / immunology
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Neoplasms / pathology
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Proteasome Endopeptidase Complex / immunology
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Proteasome Endopeptidase Complex / metabolism
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Protein Stability
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Proteolysis
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Signal Transduction
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Ubiquitin / genetics*
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Ubiquitin / immunology
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Ubiquitin-Protein Ligases / genetics*
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Ubiquitin-Protein Ligases / immunology
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p300-CBP Transcription Factors / genetics
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p300-CBP Transcription Factors / immunology
Substances
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Adaptor Proteins, Signal Transducing
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COMMD1 protein, human
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NF-kappa B
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Ubiquitin
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p300-CBP Transcription Factors
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p300-CBP-associated factor
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Ubiquitin-Protein Ligases
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Proteasome Endopeptidase Complex