Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 56, China, 2012

Guohong Huang; Wenqing Yao; Wei Yu; Lingling Mao; Haibo Sun; Wei Yao; Jiang Tian; Ling Wang; Zhijian Bo; Zhen Zhu; Yan Zhang; Zhuo Zhao; Wenbo Xu

doi:10.1371/journal.pone.0110781

Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 56, China, 2012

PLoS One. 2014 Oct 24;9(10):e110781. doi: 10.1371/journal.pone.0110781. eCollection 2014.

Authors

Guohong Huang¹, Wenqing Yao², Wei Yu², Lingling Mao², Haibo Sun², Wei Yao³, Jiang Tian², Ling Wang², Zhijian Bo³, Zhen Zhu⁴, Yan Zhang⁴, Zhuo Zhao², Wenbo Xu⁴

Affiliations

¹ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Clinical laboratory, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
² Liaoning Center for Disease Control and Prevention, Shenyang, Liaoning Province, People's Republic of China.
³ Dalian Center for Disease Control and Prevention, Dalian, Liaoning Province, People's Republic of China.
⁴ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Abstract

HAdV-56 is a new recombinant type isolated from epidemic keratoconjunctivitis (EKC) patients and has been sporadically isolated in Japan several times. Here, an outbreak of EKC in the city of Dalian, China involving a large number of workers in two factories was reported; this was the first outbreak of EKC associated with HAdV-56 worldwide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenoviruses, Human / genetics
Adolescent
Adult
Cell Line, Tumor
China / epidemiology
Disease Outbreaks / statistics & numerical data*
Genome, Viral / genetics
Humans
Keratoconjunctivitis / epidemiology*
Keratoconjunctivitis / virology*
Phylogeny
Young Adult

Grants and funding

This study was supported by National Basic Research Program of China (973 Program): (Grant No. 2011CB504902); Key Technologies R&D Program of National Ministry of Science (Grant No. 2013ZX10004-202; 2012ZX10004201-003). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.