A facile and general approach to 3-((trifluoromethyl)thio)-4H-chromen-4-one

Org Lett. 2014 Nov 7;16(21):5686-9. doi: 10.1021/ol502751k. Epub 2014 Oct 22.

Abstract

A facile and efficient synthetic strategy to 3-((trifluoromethyl)thio)-4H-chromen-4-one was developed. AgSCF3 and trichloroisocyanuric acid were employed here to generate active electrophilic trifluoromethylthio species in situ. This reaction could proceed under mild conditions in a short reaction time and be insensitive to air and moisture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Chromones / chemical synthesis*
  • Chromones / chemistry
  • Hydrocarbons, Halogenated / chemistry*
  • Molecular Structure
  • Silver / chemistry*
  • Triazines / chemistry*

Substances

  • 3-((trifluoromethyl)thio)-4H-chromen-4-one
  • Chromones
  • Hydrocarbons, Halogenated
  • Triazines
  • trichloroisocyanuric acid
  • Silver