Abstract
Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.
Keywords:
Epstein-Barr virus; NK/T cell lymphoma; mediastinum.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adult
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Biomarkers, Tumor / analysis
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Biopsy
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Epididymis / immunology
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Epididymis / pathology*
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Epididymis / virology
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Fatal Outcome
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Genital Neoplasms, Male / immunology
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Genital Neoplasms, Male / pathology*
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Genital Neoplasms, Male / virology
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Herpesvirus 4, Human / genetics
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Humans
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Immunohistochemistry
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In Situ Hybridization
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Lymphoma, Extranodal NK-T-Cell / immunology
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Lymphoma, Extranodal NK-T-Cell / pathology*
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Lymphoma, Extranodal NK-T-Cell / virology
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Male
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Mediastinal Neoplasms / immunology
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Mediastinal Neoplasms / pathology*
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Mediastinal Neoplasms / virology
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RNA, Viral / genetics
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Time Factors
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Tomography, X-Ray Computed
Substances
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Biomarkers, Tumor
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RNA, Viral