Abstract
The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.
MeSH terms
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Animals
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Bacterial Infections / diagnosis*
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Bacterial Infections / drug therapy
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Bacterial Infections / immunology
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Bacterial Infections / microbiology
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Biomarkers / blood
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C-Reactive Protein / immunology
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C-Reactive Protein / metabolism
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Disease Models, Animal
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Enzyme-Linked Immunosorbent Assay
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Gene Expression
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Humans
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Membrane Glycoproteins / antagonists & inhibitors
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Membrane Glycoproteins / blood*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology
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Mice
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Myeloid Cells / immunology
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Myeloid Cells / metabolism*
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Myeloid Cells / microbiology
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Peptides / pharmacology
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Prognosis
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Rats
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Receptors, Immunologic / antagonists & inhibitors
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Receptors, Immunologic / blood*
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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Sepsis / diagnosis*
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Sepsis / drug therapy
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Sepsis / immunology
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Sepsis / microbiology
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Triggering Receptor Expressed on Myeloid Cells-1
Substances
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Biomarkers
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Membrane Glycoproteins
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Peptides
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Receptors, Immunologic
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TREM1 protein, human
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Triggering Receptor Expressed on Myeloid Cells-1
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C-Reactive Protein