Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

Antimicrob Agents Chemother. 2015 Jan;59(1):666-8. doi: 10.1128/AAC.04055-14. Epub 2014 Oct 13.

Abstract

Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

Publication types

  • Multicenter Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Cryptococcosis / drug therapy
  • Cryptococcus gattii / drug effects*
  • Cryptococcus gattii / genetics
  • Cryptococcus neoformans / drug effects*
  • Cryptococcus neoformans / genetics
  • Genotype
  • Humans
  • Microbial Sensitivity Tests
  • Nitriles / pharmacology*
  • Nitriles / therapeutic use
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use

Substances

  • Antifungal Agents
  • Nitriles
  • Pyridines
  • Triazoles
  • isavuconazole