Increased cerebellar volume and BDNF level following quadrato motor training

Synapse. 2015 Jan;69(1):1-6. doi: 10.1002/syn.21787. Epub 2014 Oct 20.

Abstract

Using whole-brain structural measures coupled to analysis of salivary brain-derived neurotrophic factor (BDNF), we demonstrate sensory motor training-induced plasticity, including cerebellar gray matter volume increment and increased BDNF level. The increase of cerebellar volume was positively correlated with the increase of BDNF level.

Keywords: MRI; brain-derived neurotrophic factor; cerebellum; neuroplasticity; sensorimotor training.

MeSH terms

  • Adult
  • Blotting, Western
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Cerebellum / anatomy & histology*
  • Cerebellum / physiology
  • Diffusion Tensor Imaging
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Gray Matter / anatomy & histology
  • Gray Matter / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neuronal Plasticity / physiology
  • Organ Size
  • Practice, Psychological*
  • Psychomotor Performance / physiology*
  • Saliva / metabolism

Substances

  • Brain-Derived Neurotrophic Factor
  • BDNF protein, human