Cellular differences in protein synthesis regulate tissue homeostasis

Cell. 2014 Oct 9;159(2):242-51. doi: 10.1016/j.cell.2014.09.016.

Abstract

Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Homeostasis
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Organ Specificity
  • Protein Biosynthesis*
  • Ribosomes / metabolism
  • Stem Cells / metabolism
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Multiprotein Complexes
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases