Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Sanaz Eftekhari; Amene Shahrokhi; Vera Tsintsadze; Romain Nardou; Corinne Brouchoud; Magali Conesa; Nail Burnashev; Diana C Ferrari; Yehezkel Ben-Ari

doi:10.1126/science.1256009

Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Science. 2014 Oct 10;346(6206):176. doi: 10.1126/science.1256009.

Authors

Sanaz Eftekhari¹, Amene Shahrokhi², Vera Tsintsadze³, Romain Nardou⁴, Corinne Brouchoud³, Magali Conesa⁴, Nail Burnashev³, Diana C Ferrari⁴, Yehezkel Ben-Ari⁵

Affiliations

¹ Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Iran University of Medical Sciences, Tehran, Iran.
² Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Tehran University of Medical Sciences, Tehran, Iran.
³ Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France.
⁴ Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France.
⁵ Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. yehezkel.ben-ari@inserm.fr.

PMID: 25301611
DOI: 10.1126/science.1256009

Abstract

Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Autistic Disorder / chemically induced*
Autistic Disorder / genetics*
Cytoprotection*
Female
Oxytocin / metabolism*
Pregnancy
gamma-Aminobutyric Acid / metabolism*

Substances

Oxytocin
gamma-Aminobutyric Acid