Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways

Br J Haematol. 2015 Mar;168(5):765-8. doi: 10.1111/bjh.13149. Epub 2014 Oct 4.

Authors

Xiaoxian Zhao¹, Juraj Bodo, Danyu Sun, Lisa Durkin, Jeffrey Lin, Mitchell R Smith, Eric D Hsi

Affiliation

¹ Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 25284608
DOI: 10.1111/bjh.13149

No abstract available

Keywords: BCL-2; Bruton tyrosine kinase; apoptosis; mantle cell lymphoma; synergy.

Publication types

Letter

MeSH terms

Adenine / analogs & derivatives
Agammaglobulinaemia Tyrosine Kinase
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Apoptosis / drug effects*
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Synergism
Humans
Lymphoma, Mantle-Cell* / drug therapy
Lymphoma, Mantle-Cell* / metabolism
Lymphoma, Mantle-Cell* / pathology
Piperidines
Protein-Tyrosine Kinases / metabolism*
Proto-Oncogene Proteins c-akt / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Pyrazoles / agonists
Pyrazoles / pharmacology
Pyrimidines / agonists
Pyrimidines / pharmacology
Signal Transduction / drug effects*

Substances

BCL2 protein, human
Piperidines
Proto-Oncogene Proteins c-bcl-2
Pyrazoles
Pyrimidines
ibrutinib
Protein-Tyrosine Kinases
Agammaglobulinaemia Tyrosine Kinase
BTK protein, human
Proto-Oncogene Proteins c-akt
Adenine