Abstract
Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder that usually manifests with nonspecific symptoms, including fever and lymphadenopathy. Treatment of pediatric MCD varies greatly. A 21-month-old child was diagnosed with MCD after presenting with fever. He had incomplete response to initial therapy directed at interleukin-6, but improved with subsequent chemotherapy.
Copyright © 2014 Elsevier Inc. All rights reserved.
MeSH terms
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Antibodies, Monoclonal, Humanized / therapeutic use
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Antibodies, Monoclonal, Murine-Derived / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Castleman Disease / diagnosis*
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Castleman Disease / physiopathology
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Fever / drug therapy*
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Fever / etiology
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Humans
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Infant
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Interleukin-6 / metabolism
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Lymph Nodes / pathology
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Lymphocytes / pathology
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Male
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Pleural Effusion / drug therapy
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Pleural Effusion / etiology
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Prednisone / therapeutic use
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Rituximab
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Tomography, X-Ray Computed
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal, Humanized
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Antibodies, Monoclonal, Murine-Derived
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Interleukin-6
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R-CHOP protocol
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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tocilizumab
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Prednisone
Supplementary concepts
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Multi-centric Castleman's Disease