Penicillinase-producing plasmid types in Neisseria gonorrhoeae clinical isolates from Australia

David Whiley; Ella Trembizki; Cameron Buckley; Kevin Freeman; Andrew Lawrence; Athena Limnios; Julie Pearson; Helen Smith; Kerrie Stevens; Monica M Lahra

doi:10.1128/AAC.04120-14

Penicillinase-producing plasmid types in Neisseria gonorrhoeae clinical isolates from Australia

Antimicrob Agents Chemother. 2014 Dec;58(12):7576-8. doi: 10.1128/AAC.04120-14. Epub 2014 Sep 29.

Authors

Affiliations

¹ Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Health Services, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia d.whiley@uq.edu.au.
² Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Health Services, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
³ Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
⁴ Microbiology and Infectious Diseases Department, Women's and Children's Hospital, North Adelaide, Australia.
⁵ WHO Collaborating Centre for STD, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales, Australia.
⁶ PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia.
⁷ Public Health Microbiology, Communicable Disease, Queensland Health Forensic and Scientific Services, Archerfield, Queensland, Australia.
⁸ Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Abstract

Penicillinase-producing Neisseria gonorrhoeae (PPNG) carrying the blaTEM-135 gene is of particular concern, as it is considered a stepping stone toward resistance to extended-spectrum cephalosporins. Here, we sought to characterize plasmid types and the occurrence of the blaTEM-135 gene for N. gonorrhoeae clinical isolates from Australia. We found that blaTEM-135 was prevalent in Australian PPNG and was detected on all three major plasmid types.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Australia
Bacterial Typing Techniques
Cephalosporin Resistance / genetics*
Cephalosporins / pharmacology
Gonorrhea / microbiology
Gonorrhea / transmission
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae / classification
Neisseria gonorrhoeae / drug effects
Neisseria gonorrhoeae / genetics*
Neisseria gonorrhoeae / isolation & purification
Penicillin Resistance / genetics*
Penicillinase / genetics*
Penicillins / pharmacology
Plasmids / chemistry*
Plasmids / classification

Substances

Anti-Bacterial Agents
Cephalosporins
Penicillins
Penicillinase