Subphthalocyanines: addressing water-solubility, nano-encapsulation, and activation for optical imaging of B16 melanoma cells

Chem Commun (Camb). 2014 Nov 21;50(90):13975-8. doi: 10.1039/c4cc05503a. Epub 2014 Sep 30.

Abstract

Water-soluble disulfonato-subphthalocyanines (SubPcs) or hydrophobic nano-encapsulated SubPcs are efficient probes for the fluorescence imaging of cells. 20 nm large liposomes (TEM and DLS) incorporated about 13% SubPc. Moreover, some of these fluorophores were found to be pH activatable.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Hydrogen-Ion Concentration
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Isoindoles
  • Liposomes / chemistry
  • Melanoma, Experimental / pathology*
  • Mice
  • Models, Molecular
  • Molecular Imaging*
  • Molecular Structure
  • Nanostructures / chemistry*
  • Solubility
  • Water / chemistry

Substances

  • Fluorescent Dyes
  • Indoles
  • Isoindoles
  • Liposomes
  • Water
  • phthalocyanine