Abstract
Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aspergillus / chemistry*
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Aspergillus / genetics
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Biological Products / chemistry
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Biological Products / metabolism*
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Biological Products / pharmacology
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Biosynthetic Pathways / genetics
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Molecular Structure
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Multigene Family*
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Quinones / chemistry
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Quinones / metabolism
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Quinones / pharmacology
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Salicylates / chemistry
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Salicylates / metabolism
Substances
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Biological Products
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Quinones
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Salicylates
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6-methylsalicylic acid
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terreic acid