Acyclovir-resistant, foscarnet-sensitive oral herpes simplex type 2 lesion in a patient with AIDS

Oral Surg Oral Med Oral Pathol. 1989 Apr;67(4):427-32. doi: 10.1016/0030-4220(89)90386-1.

Abstract

We report the case of an immunocompromised patient with AIDS in whom developed a perioral and several intraoral HSV 2 lesions that persisted for more than 1 year. The virus was resistant to acyclovir but was sensitive to foscarnet. Viral isolates were thymidine kinase negative. The lesions resolved with intravenous foscarnet therapy given over a 15-week period, and when last seen, 8 months after foscarnet was discontinued, the patient had not had a recurrence.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acyclovir / therapeutic use*
  • Adult
  • Antiviral Agents / therapeutic use*
  • Candidiasis, Oral / complications
  • Drug Resistance, Microbial
  • Facial Dermatoses / complications
  • Facial Dermatoses / drug therapy*
  • Foscarnet
  • Herpes Simplex / complications
  • Herpes Simplex / drug therapy*
  • Humans
  • Male
  • Organophosphorus Compounds / therapeutic use*
  • Phosphonoacetic Acid / analogs & derivatives
  • Phosphonoacetic Acid / therapeutic use*
  • Stomatitis, Herpetic / complications
  • Stomatitis, Herpetic / drug therapy*

Substances

  • Antiviral Agents
  • Organophosphorus Compounds
  • Foscarnet
  • Phosphonoacetic Acid
  • Acyclovir