Unraveling the miswired connectome: a developmental perspective

Adriana Di Martino; Damien A Fair; Clare Kelly; Theodore D Satterthwaite; F Xavier Castellanos; Moriah E Thomason; R Cameron Craddock; Beatriz Luna; Bennett L Leventhal; Xi-Nian Zuo; Michael P Milham

doi:10.1016/j.neuron.2014.08.050

Unraveling the miswired connectome: a developmental perspective

Neuron. 2014 Sep 17;83(6):1335-53. doi: 10.1016/j.neuron.2014.08.050.

Authors

Affiliations

¹ Department of Child and Adolescent Psychiatry, Child Study Center at NYU Langone Medical Center, New York, NY 10016, USA.
² Behavioral Neuroscience and Psychiatry Departments and Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR 97329, USA.
³ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴ Department of Child and Adolescent Psychiatry, Child Study Center at NYU Langone Medical Center, New York, NY 10016, USA; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
⁵ Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI 48202, USA; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA.
⁶ Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA.
⁷ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
⁸ Department of Psychiatry, Langley Porter Psychiatric Institute, University of California San Francisco, San Francisco, CA 94143, USA.
⁹ Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China; Faculty of Psychology, Southwest University, Beibei, Chongqing 100101, China.
¹⁰ Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA. Electronic address: michael.milham@childmind.org.

Abstract

The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / physiopathology*
Child
Connectome / methods*
Humans
Mental Disorders / physiopathology*
Models, Neurological*

Abstract

Publication types

MeSH terms

Grants and funding