Abstract
The effect of intravenous injection of Fab' fragments of anti-L3T4 antibody (GK1.5 monoclonal antibody) into mice was studied. This treatment depleted L3T4+ cells from the popliteal lymph nodes of keyhole-limpet hemocyanin-primed mice. The T cells that remained were unable to provide help to antigen-specific B cells in vitro. The results obtained using Fab' fragments were comparable with those using intact anti-L3T4 antibody and demonstrate that either form of GK1.5 is a potentially useful immunosuppressive agent in mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Antibody Formation
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Antigens, Differentiation, T-Lymphocyte / immunology*
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Immunoglobulin Fab Fragments / immunology
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Isoantibodies / immunology*
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Lymph Nodes / immunology*
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Lymphocyte Cooperation
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Mice
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Mice, Inbred BALB C
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation, T-Lymphocyte
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Immunoglobulin Fab Fragments
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Isoantibodies