Antifungal activities of triterpenoids from the roots of Astilbe myriantha Diels

Qiu-Yan Song; Wei-Yan Qi; Zheng-Ming Li; Jie Zhao; Jian-Jun Chen; Kun Gao

doi:10.1016/j.foodchem.2011.03.059

Antifungal activities of triterpenoids from the roots of Astilbe myriantha Diels

Food Chem. 2011 Sep 15;128(2):495-9. doi: 10.1016/j.foodchem.2011.03.059. Epub 2011 Mar 16.

Authors

Qiu-Yan Song¹, Wei-Yan Qi¹, Zheng-Ming Li¹, Jie Zhao¹, Jian-Jun Chen², Kun Gao³

Affiliations

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
² State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: chenjj@lzu.edu.cn.
³ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: npchem@lzu.edu.cn.

PMID: 25212161
DOI: 10.1016/j.foodchem.2011.03.059

Abstract

During a search for plant extracts that possess activity against the fungi that cause diseases in plants, a 95% ethanol extract from the roots of Astilbe myriantha Diels showed inhibitory activity against Colletotrichum gloeosporioides. Bioassay-guided fractionation of the 95% ethanol extract led to the isolation of seven triterpenoids (1-7). Their structures were elucidated by spectroscopy and by a comparison with literature data. Among these compounds, 3β,6β,24-trihydroxyurs-12-en-27-oic acid (7) was the most active inhibitor of C. gloeosporioides, with >68.0% inhibition at 100mg/ml after 72h. Moreover, compound 7 displayed broad-spectrum inhibitory activity against Rhizoctonia solani, Fusarium oxysporum f. sp. Niveum, Fusarium oxysporum f. sp. Cubens, C. gloeosporioides, Penicillium citrinum, Colletotrichum lagenarium, and Penicillium digitatum, with EC50 values ranging from 13.9 to 34.0μg/ml. The potential of compound 7 as a fungicide is therefore promising. In addition, compound 1 was found to be a new triterpenoid, 3β,6β-dihydroxyurs-12-en-7α,27α-olide, which possesses six rings.

Keywords: Antifungal activity; Astilbe myriantha Diels; Triterpenoids.