Sensitivity of a time-based prospective memory procedure in the assessment of amnestic mild cognitive impairment

Alberto Costa; Lucia Fadda; Roberta Perri; Marialuisa Brisindi; Maria Giovanna Lombardi; Carlo Caltagirone; Giovanni Augusto Carlesimo

doi:10.3233/JAD-142070

Sensitivity of a time-based prospective memory procedure in the assessment of amnestic mild cognitive impairment

J Alzheimers Dis. 2015;44(1):63-7. doi: 10.3233/JAD-142070.

Authors

Alberto Costa¹, Lucia Fadda², Roberta Perri¹, Marialuisa Brisindi¹, Maria Giovanna Lombardi¹, Carlo Caltagirone², Giovanni Augusto Carlesimo²

Affiliations

¹ I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
² I.R.C.C.S. Fondazione S. Lucia, Rome, Italy Università di Roma "Tor Vergata", Rome, Italy.

PMID: 25208618
DOI: 10.3233/JAD-142070

Abstract

This study was aimed at evaluating whether prospective memory (PM) assessment is able to assist the discrimination between amnestic mild cognitive impairment (aMCI) and healthy subjects (HCs) and between aMCI with single versus multiple domains impairment. Individuals with aMCI and HCs were administered an extensive neuropsychological tests battery and a time-based PM task. PM scores significantly improved the accuracy of the regression model in discriminating between aMCI multiple domains, but not aMCI single domain, and HCs. Moreover, the prospective score significantly contributed to the discrimination between the two aMCI subgroups. These findings indicate the usefulness of including the PM procedure in evaluations of aMCI.

Keywords: Dementia; mild cognitive impairment; neuropsychological assessment; prospective memory.

MeSH terms

Aged
Aged, 80 and over
Amnesia / complications*
Cognitive Dysfunction / complications*
Cognitive Dysfunction / diagnosis*
Female
Humans
Male
Memory, Episodic*
Middle Aged
Neuropsychological Tests*
Sensitivity and Specificity
Time Factors