The objective of the study was to analyze the Multiple Myeloma (MM) incidence in clean-up workers preparing the information background for consequent analytical study with a dose-dependent risk estimates.
Materials and methods: The Cohort Database was linked to the Ukrainian National Cancer Registry to identify the MM cases in a cohort of 152 520 male clean-up workers.
Results: The 64 MM cases were identified in the studied Cohort for the 1987-2012 period. Fifty-eight of them were included to the preliminary incidence analysis accounting for the 10-years lag-period. According to the preliminary data analysis the MM incidence rate in studied clean-up workers Cohort did not exceed the corresponding rate in general population of Ukraine along the 21 years after the catastrophe.
Conclusions: Standardized incidence ratio for the 2008-2012 period, that is 22-26 years after the accident, demonstrated the significant excess of MM incidence among male clean-up workers in comparison with general population of Ukraine of corresponding age and gender (SIR 1.61, 95% CI 1.01;2.21).
Meta: proanalizuvaty zahvorjuvanist' na mnozhynnu mijelomu (MM) sered uchasnykiv likvidacii' naslidkiv Chornobyl's'koi' katastrofy (ULNA) ta pidgotuvaty informacijnu osnovu dlja podal'shogo analitychnogo doslidzhennja dozozalezhnyh ryzykiv cijei' patologii', vrahovujuchy i'i' potencijnu radiacijnu zumovlenist'. Materialy i metody. Dlja identyfikacii' vypadkiv MM u doslidzhuvanij kogorti ULNA chysel'nistju 152 520 osib cholovichoi' stati buv provedenyj linkidzh bazy danyh kogorty z informacijnym masyvom Nacional'nogo kancerrejestru Ukrai'ny. Rezul'taty. Za doslidzhuvanyj period (1987–2012 rr.) bulo identyfikovano 64 vypadky, 58 z jakyh buly vkljucheni do poperedn'ogo analizu zahvorjuvanosti, vrahovujuchy 10-richnyj lag-period. Za rezul'tatamy poperedn'ogo analizu zahvorjuvanist' na MM u doslidzhuvanij kogorti ULNA ne perevyshhuvala harakternyj dlja zagal'nogo naselennja riven' protjagom pershyh 21 rokiv pislja avarii'. Vysnovok. Rozrahunok standartyzovanogo spivvidnoshennja zahvorjuvanosti (SIR) za period 2008–2012 rr., tobto cherez 22–26 rokiv pislja avarii', prodemonstruvav dostovirne perevyshhennja rivnja sered ULNA porivnjano zi spontannym populjacijnym rivnem dlja naselennja Ukrai'ny cholovichoi' stati (SIR 1.61, 95% CI 1.01;2.21). Pislja provedennja nezalezhnoi' diagnostychnoi' ekspertyzy vsih identyfikovanyh vypadkiv, rekonstrukcii' otrymanoi' dozy zovnishn'ogo oprominennja na chervonyj kistkovyj mozok za metodom RADRUE budut' proanalizovani dozozalezhni ryzyky vynyknennja MM z urahuvannjam mozhlyvogo modyfikujuchogo vplyvu inshyh faktoriv.
Keywords: Chornobyl accident; clean-up workers; incidence; multiple myeloma.
Bazyka D. A., Gudzenko N. A., Dyagil I. S., Babkina N. G., Chumak V. V., Bakhanova E. V., Paramonov V. V., Romanenko A. Ye., 2013.