Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions

Roberta Rizzo; Valentina Gentili; Antonella Rotola; Daria Bortolotti; Enzo Cassai; Dario Di Luca

doi:10.1089/vim.2014.0017

Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions

Viral Immunol. 2014 Nov;27(9):468-70. doi: 10.1089/vim.2014.0017. Epub 2014 Sep 4.

Authors

Roberta Rizzo¹, Valentina Gentili, Antonella Rotola, Daria Bortolotti, Enzo Cassai, Dario Di Luca

Affiliation

¹ Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara , Ferrara, Italy .

PMID: 25188020
DOI: 10.1089/vim.2014.0017

Abstract

Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 condyloma acuminatum, and 111 invasive cervical cancer (ICC) patients. We showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in HPV high-risk infected patients (OR 3.05, 3.24) with ICC (OR 1.33, 3.68). These data suggest HLA-C and KIR typing as risk marker for HPV infection and lesion evolution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Gene Frequency
HLA-C Antigens / genetics*
Humans
Middle Aged
Papillomavirus Infections / complications
Papillomavirus Infections / genetics*
Receptors, KIR / genetics*
Risk Assessment
Uterine Cervical Neoplasms / genetics*
Young Adult

Substances

HLA-C Antigens
Receptors, KIR