When autophagy chaperones liver metabolism

Patrice Codogno; Sophie Lotersztajn

doi:10.1016/j.cmet.2014.08.008

When autophagy chaperones liver metabolism

Cell Metab. 2014 Sep 2;20(3):392-3. doi: 10.1016/j.cmet.2014.08.008.

Authors

Patrice Codogno¹, Sophie Lotersztajn²

Affiliations

¹ INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM), 75014 Paris, France; Université Paris Descartes-Sorbonne Paris Cité, 70014 Paris, France. Electronic address: patrice.codogno@inserm.fr.
² INSERM U1149, Center for research on Inflammation, 75018 Paris, France; Université Paris Diderot-Sorbonne Paris Cité, Faculté de Médecine, Site Xavier Bichat, 75018 Paris, France. Electronic address: sophie.lotersztajn@inserm.fr.

PMID: 25185945
DOI: 10.1016/j.cmet.2014.08.008

Abstract

Chaperone-mediated autophagy (CMA) governs degradation of cytosolic proteins damaged by nutritional changes and declines with age. In this issue, Schneider et al. (2014) reveal CMA as a novel player in the regulation of liver lipid and carbohydrate metabolism and suggest that defects in CMA may play a major role in metabolic dysregulation.

Publication types

Comment

MeSH terms

Animals
Autophagy*
Fatty Liver / genetics*
Fatty Liver / pathology*
Female
Liver / metabolism*
Liver / pathology*
Lysosomal-Associated Membrane Protein 2 / genetics*
Male

Substances

Lysosomal-Associated Membrane Protein 2