Combined optical and electronic sensing of epithelial cells using planar organic transistors

Adv Mater. 2014 Nov 5;26(41):7083-90. doi: 10.1002/adma.201401706. Epub 2014 Sep 1.

Abstract

A planar, conducting-polymer-based transistor for combined optical and electronic monitoring of live cells provides a unique platform for monitoring the health of cells in vitro. Monitoring of MDCK-I epithelial cells over several days is shown, along with a demonstration of the device for toxicology studies, of use in future drug discovery or diagnostics applications.

Keywords: MDCK cells; barrier tissue; conducting polymers; poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS); tight junctions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dogs
  • Electrical Equipment and Supplies*
  • Epithelial Cells / cytology*
  • Madin Darby Canine Kidney Cells
  • Optical Devices*
  • Polystyrenes / chemistry*
  • Thiophenes / chemistry*
  • Transistors, Electronic*

Substances

  • Polystyrenes
  • Thiophenes
  • poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)