1 Departments of Anesthesia and Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, Ohio 45229, USA Department of Pediatrics and Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of Pediatrics and Division of Rheumatology, Cincinnati Children's Hospital Medical Center, and Cincinnati VA Medical Center, Cincinnati, Ohio, USA.