The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor

Science. 1989 Dec 15;246(4936):1412-6. doi: 10.1126/science.2512641.

Abstract

A protein secreted by cultured rat heart cells can direct the choice of neurotransmitter phenotype made by cultured rat sympathetic neurons. Structural analysis and biological assays demonstrated that this protein is identical to a protein that regulates the growth and differentiation of embryonic stem cells and myeloid cells, and that stimulates bone remodeling and acute-phase protein synthesis in hepatocytes. This protein has been termed D factor, DIA, DIF, DRF, HSFIII, and LIF. Thus, this cytokine, like IL-6 and TGF beta, regulates growth and differentiation in the embryo and in the adult in many tissues, now including the nervous system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Differentiation
  • Cells, Cultured
  • Choline / physiology*
  • Cloning, Molecular
  • DNA / genetics
  • Growth Inhibitors* / genetics
  • Growth Inhibitors* / metabolism
  • Growth Inhibitors* / pharmacology
  • Humans
  • Immunosorbent Techniques
  • Interleukin-6*
  • Leukemia Inhibitory Factor
  • Lymphokines*
  • Mice
  • Molecular Sequence Data
  • Myocardium / metabolism*
  • Neurons / cytology*
  • Rats
  • Sequence Homology, Nucleic Acid

Substances

  • Growth Inhibitors
  • Interleukin-6
  • LIF protein, human
  • Leukemia Inhibitory Factor
  • Lif protein, mouse
  • Lymphokines
  • DNA
  • Choline