A smart "sense-act-treat" system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage

Peng Shi; Zhen Liu; Kai Dong; Enguo Ju; Jinsong Ren; Yingda Du; Zhengqiang Li; Xiaogang Qu

doi:10.1002/adma.201402522

A smart "sense-act-treat" system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage

Adv Mater. 2014 Oct;26(38):6635-41. doi: 10.1002/adma.201402522. Epub 2014 Aug 15.

Authors

Peng Shi¹, Zhen Liu, Kai Dong, Enguo Ju, Jinsong Ren, Yingda Du, Zhengqiang Li, Xiaogang Qu

Affiliation

¹ Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, University of Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.

PMID: 25124557
DOI: 10.1002/adma.201402522

Abstract

Herein, we design a "sense-act-treat" system via the combination of a ratiometric pH sensor with a therapeutic gold nanocage. Our design could "sense" the tumor through two-state switching of fluorescence and further provide chemotherapy and hyperthermia for "treating" the tumor, showing the potential for future biomedical applications.

Keywords: NIR; gold nanocage; nanomedicine; ratiometry; theranostics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gold / chemistry*
Gold / therapeutic use*
HeLa Cells
Humans
Hydrogen-Ion Concentration
Infrared Rays*
Metal Nanoparticles*
Nanomedicine / instrumentation*
Polymers / chemistry

Substances

Polymers
Gold