Directed arene/alkyne annulation reactions via aerobic copper catalysis

Org Biomol Chem. 2014 Nov 28;12(44):8844-50. doi: 10.1039/c4ob01312c.

Abstract

We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen. 3-Methyleneisoindoline derivatives are prepared in high yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Benzene Derivatives / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Hydrogenation
  • Isoindoles / chemical synthesis*
  • Isoindoles / chemistry
  • Molecular Structure
  • Oxygen / chemistry

Substances

  • Alkynes
  • Benzene Derivatives
  • Isoindoles
  • Copper
  • Oxygen