Targeted delivery of cisplatin by сonnexin 43 vector nanogels to the focus of experimental glioma C6

Bull Exp Biol Med. 2014 Aug;157(4):524-9. doi: 10.1007/s10517-014-2606-x. Epub 2014 Aug 12.

Abstract

The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects of Cx43-modified cisplatin-loaded nanogels, free cisplatin, and nonspecific drugs were carried out on C6 glioma model. Vector nanogels reduced systemic toxicity of cisplatin, effectively inhibited tumor growth, and significantly prolonged the lifespan of animals with experimental tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Brain Neoplasms / immunology
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Cisplatin / chemistry
  • Cisplatin / pharmacology*
  • Connexin 43 / chemistry
  • Connexin 43 / immunology*
  • Drug Carriers
  • Female
  • Gels
  • Glioblastoma / immunology
  • Glioblastoma / mortality
  • Glioblastoma / pathology
  • Glioblastoma / therapy*
  • Immunoconjugates / chemistry
  • Immunoconjugates / pharmacology*
  • Mice
  • Mice, Inbred BALB C
  • Nanostructures / chemistry
  • Neoplasm Transplantation
  • Polyethylene Glycols / chemistry
  • Polymethacrylic Acids / chemistry
  • Protein Structure, Tertiary
  • Rats
  • Rats, Wistar
  • Stereotaxic Techniques
  • Survival Analysis
  • Tumor Burden / drug effects

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Connexin 43
  • Drug Carriers
  • Gels
  • Immunoconjugates
  • Polymethacrylic Acids
  • polymethacrylic acid
  • Polyethylene Glycols
  • Cisplatin