Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis

Mol Cell Endocrinol. 2014 Nov;397(1-2):42-50. doi: 10.1016/j.mce.2014.08.002. Epub 2014 Aug 7.

Abstract

The mammalian sirtuins (SIRT1-7) are a family of highly conserved nicotine adenine dinucleotide (NAD(+))-dependent deacetylases that act as cellular sensors to detect energy availability. SIRT1 is a multifaceted protein that is involved in a wide variety of cellular processes. SIRT1 is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. SIRT1 regulates the role of multiple hormones implicated in energy balance, including glucose and lipid metabolism. Here, we review the relevant role of SIRT1 as a mediator of endocrine function of several hormones to modulate energy balance. In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus.

Keywords: Food intake; Hormones; Insulin; Obesity; SIRT1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / metabolism
  • Animals
  • Circadian Clocks
  • Energy Metabolism / physiology*
  • Glucagon-Like Peptide 1 / metabolism
  • Glucose / metabolism
  • Homeostasis*
  • Humans
  • Incretins / metabolism
  • Insulin / metabolism
  • Mice
  • Rats
  • Sirtuin 1 / metabolism
  • Sirtuin 1 / physiology*

Substances

  • Adipokines
  • Incretins
  • Insulin
  • Glucagon-Like Peptide 1
  • Sirtuin 1
  • Glucose