Eyes on the prize: limbal stem cells and corneal restoration

Cell Stem Cell. 2014 Aug 7;15(2):121-2. doi: 10.1016/j.stem.2014.07.011.

Abstract

Corneal diseases and blindness can result from deficiency in limbal stem cells, and autologous transplantation is often the only therapeutic option. Two recent studies in Nature have provided insights into regulation of limbal stem cell function and corneal regeneration and present new opportunities for clinical interventions in eye diseases.

Publication types

  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Corneal Diseases / metabolism*
  • Corneal Diseases / pathology*
  • Epithelium, Corneal / cytology*
  • Epithelium, Corneal / metabolism*
  • Eye Proteins / metabolism*
  • Female
  • Homeodomain Proteins / metabolism*
  • Homeostasis*
  • Humans
  • Limbus Corneae / cytology*
  • Limbus Corneae / physiology*
  • Male
  • Paired Box Transcription Factors / metabolism*
  • Regeneration*
  • Repressor Proteins / metabolism*
  • Stem Cells / metabolism*
  • Wnt Proteins / metabolism*
  • Wound Healing*

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters
  • Eye Proteins
  • Homeodomain Proteins
  • Paired Box Transcription Factors
  • Repressor Proteins
  • Wnt Proteins