Tandem Michael addition/imine isomerization/intramolecular [3+2] cycloaddition for the regiospecific synthesis of cyclohepta[b]pyrroles

Chem Commun (Camb). 2014 Sep 28;50(75):11039-42. doi: 10.1039/c4cc04665j. Epub 2014 Aug 7.

Abstract

The polarity reversible nature of azomethine imines as the crucial transformation enables the tandem Michael addition/imine isomerization/[3+2] cycloaddition to proceed under mild, transition-metal-free conditions to form cyclohepta[b]pyrroles in a single operation starting from readily available acyclic precursors with a broad substrate scope.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry
  • Cycloaddition Reaction
  • Imines / chemistry*
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry*
  • Stereoisomerism
  • Thiosemicarbazones / chemistry

Substances

  • Azo Compounds
  • Imines
  • Pyrroles
  • Thiosemicarbazones
  • azomethine