Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Jolanta Maciejewska; Marek Jankowski; Barbara Zegarska; Rafał Czajkowski

doi:10.5114/pdia.2014.40796

Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Postepy Dermatol Alergol. 2014 Jun;31(3):194-6. doi: 10.5114/pdia.2014.40796. Epub 2014 Jun 13.

Authors

Jolanta Maciejewska¹, Marek Jankowski¹, Barbara Zegarska², Rafał Czajkowski¹

Affiliations

¹ Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Rafał Czajkowski MD, PhD, DSc, Assoc. Prof.
² Department of Cosmetology and Esthetic Dermatology, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Barbara Zegarska MD, PhD, Prof. NCU.

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous, unpredictable, life-threatening drug side reactions. A very rare case of norfloxacin-induced SJS/TEN overlap with uncommon clinical presentation in a patient with a suspected urinary tract infection is reported. The SJS/TEN management with possible treatment capabilities are discussed. In spite of only two previous reports of norfloxacin-induced SJS and TEN we believe that awareness of norfloxacin adverse reactions needs to be raised among prescribers.

Keywords: Stevens-Johnson syndrome; norfloxacin; toxic epidermal necrolysis.

Publication types

Case Reports